In Kids, Survival of LC Histiocytosis Achieved in Most Cases
MINNEAPOLIS — Many forms of histiocytoses in children are skin-limited and relatively benign, but fatalities related to Langerhans cell histiocytosis (LCH), a relatively severe form, are increasingly uncommon unless high-risk organs are affected, according to a global expert. Because of a growing array of targeted therapies, “we have survival rates approaching 100% when children with LCH are managed by a multidisciplinary team. Skin-Only LCH Is Usually Treatment Responsive With skin-only disease, healing is typically achieved with minimal sequelae — such as minor scarring or dyspigmentation — but the risk for recurrence, most often occurring in the organ previously affected, still approaches 20%.
- ▪MINNEAPOLIS — Many forms of histiocytoses in children are skin-limited and relatively benign, but fatalities related to Langerhans cell histiocytosis (LCH), a relatively severe form, are increasingly uncommon unless high-risk organs are aff
- ▪Because of a growing array of targeted therapies, “we have survival rates approaching 100% when children with LCH are managed by a multidisciplinary team.
- ▪Skin-Only LCH Is Usually Treatment Responsive With skin-only disease, healing is typically achieved with minimal sequelae — such as minor scarring or dyspigmentation — but the risk for recurrence, most often occurring in the organ previousl
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| Original publisher | Medscape Medical News Headlines |
| Canonical URL | https://www.medscape.com/viewarticle/kids-survival-lc-histiocytosis-now-achieved-all-most-severe-2026a1000p8r?src=rss |
| Publication time | Fri, 24 Jul 2026 14:12:52 EDT |
| Retrieval time | 2026-07-25T04:44:09.294Z |
| Last seen | 2026-07-25T04:44:09.294Z |
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MINNEAPOLIS — Many forms of histiocytoses in children are skin-limited and relatively benign, but fatalities related to Langerhans cell histiocytosis (LCH), a relatively severe form, are increasingly uncommon unless high-risk organs are affected, according to a global expert. Because of a growing array of targeted therapies, “we have survival rates approaching 100% when children with LCH are managed by a multidisciplinary team. This was once not the case,” reported Mark Koh, MD, senior consultant and head of the Department of Dermatology at the KK Women’s and Children’s Hospital in Singapore.Survival rates fall substantially when the hematopoietic system, the liver, or the spleen are involved, particularly if there is a poor response to initial therapies, but long-term survival is…
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