Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm
Long-term use of finasteride and dutasteride may pose significant health risks. These medications, commonly prescribed for benign prostatic hyperplasia and male pattern hair loss, can lead to conditions such as non-alcoholic fatty liver disease and type 2 diabetes. The potential for long-lasting pathophysiological harm associated with these drugs is still not fully understood.
- ▪Finasteride and dutasteride inhibit the production of 5α-dihydrotestosterone, which plays a crucial role in various physiological functions.
- ▪Long-term use of these medications may contribute to metabolic dysfunctions, including insulin resistance and kidney issues.
- ▪Emerging literature suggests that the blockade of 5α-reductases could result in a novel state of androgen deficiency.
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| Original publisher | Nih |
| Canonical URL | https://pmc.ncbi.nlm.nih.gov/articles/PMC7308241/ |
| Publication time | Thu, 21 May 2026 02:07:53 +0000 |
| Retrieval time | 2026-05-21T02:35:03.339Z |
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World J Mens Health. 2020 Mar 20;38(3):323–337. doi: 10.5534/wjmh.200012 Search in PMC Search in PubMed View in NLM Catalog Add to search Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm Abdulmaged M Traish Abdulmaged M Traish 1Department of Urology, Boston University School of Medicine, Boston, MA, USA. Find articles by Abdulmaged M Traish 1,✉ Author information Article notes Copyright and License information 1Department of Urology, Boston University School of Medicine, Boston, MA, USA. ✉Correspondence to: Abdulmaged M. Traish. Department of Urology, Boston University School of Medicine, Building A Room 502, 72 East Newton Street, Boston, MA 02118, USA. Tel: +1-617-358-7561, [email protected] ✉Corresponding author.
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