Nonpharmacologics May Reduce Anxiety, Depression in SUD
A large meta-analysis indicates that nonpharmacologic interventions can significantly improve anxiety and depression symptoms in individuals with substance use disorder (SUD). Neuromodulation and mind-body therapy (MBT) were found to be particularly effective, while improvements in quality of life were less pronounced. The study highlights the variability in effectiveness based on intervention type, duration, and country development level.
- ▪The meta-analysis included 117 randomized controlled trials with 11,177 participants from 25 countries.
- ▪Significant reductions in anxiety symptoms were observed with neuromodulation, combined intervention, MBT, relapse prevention, and acupuncture.
- ▪Neuromodulation was ranked as the most effective option for anxiety and quality of life, while MBT was most effective for depression.
Medscape files mainly under health. We currently carry 231 of its stories.
Story provenance
Source · retrieval · rights · ranking — open for full record
inspect →
Story provenance
Attribution is not the same as permission. This drawer separates discovery metadata, excerpts, WeSearch-generated summaries, reuse status, and whether the publisher receives the visit. Nothing here claims a legal grant the publisher has not made.
Record
| Original publisher | Medscape |
| Canonical URL | https://www.medscape.com/viewarticle/nonpharmacologics-may-reduce-anxiety-depression-sud-2026a1000g9v?src=rss |
| Publication time | Wed, 20 May 2026 01:47:30 EDT |
| Retrieval time | 2026-05-20T06:05:00.300Z |
| Last seen | 2026-05-20T06:05:00.300Z |
| Headline source | Publisher (no WeSearch rewrite) |
| Excerpt source | publisher body |
| Excerpt method | First ~120 words (~800 chars) of extracted publisher body, fair-use limited. |
| Summary | WeSearch · cerebras-chat (WeSearch summarizer) |
| Summary source text | contentText |
| Citation coverage | Summary is a WeSearch-generated derivative; primary citation is the original publisher URL. |
| Cluster | AqjDT0sB73sL |
| Cluster logic | Grouped by semantic title/content similarity across sources within a rolling window. Same-publisher template collisions are excluded from coverage comparison. |
| Ranking reason | Story pages are not engagement-ranked. Hub feeds use recency, with optional source-diversified chronological ordering (cap consecutive stories per source). No personalized ranking. |
| Publisher visit | Yes — open original |
| Substitutes article? | No — link-out required for full text |
Rights status (four layers)
WeSearch handling by dimension
| Indexing | May the item be indexed (stored, ranked, made findable)? | Allowed |
| Snippet | May a short excerpt of the publisher's text be shown? | Allowed |
| AI summary | May WeSearch generate its own short summary of the article? | Limited |
| Retrieval / RAG | May the content be exposed for third-party retrieval-augmented generation? | Not asserted |
| Model training | May the content be used to train AI models? | Not asserted |
| Commercial reuse | May the content be reused commercially? | Not permitted |
Basis: Derived from the published RSS/Atom feed. Contact: [email protected]. Reviewed: 2026-07-24.
Opening excerpt (first ~120 words) tap to expand
TOPLINE:Nonpharmacologic interventions — particularly neuromodulation and mind-body therapy (MBT) — are associated with significant improvements in psychiatric symptoms in people with substance use disorder (SUD), a new large meta-analysis showed. However, evidence for short-term improvement in quality of life (QOL) was low.METHODOLOGY:A systematic review and network meta-analysis of 117 randomized controlled trials including 11,177 individuals (mean age, 19-57 years) with SUDs from 25 countries was conducted to compare the relative efficacy of nonpharmacologic interventions for anxiety, depression, and QOL.Intervention durations ranged from 5 days to 12 months and 19 nonpharmacologic interventions were analyzed, including neuromodulation, MBT, conventional exercise, cognitive-behavioral…
Excerpt limited to ~120 words for fair-use compliance. The full article is at Medscape.
Discussion
0 commentsMore from Medscape
