Study: Single dose of psilocybin provided rapid relief from depression
A recent study indicates that a single dose of psilocybin can provide rapid relief from depression symptoms within days. Conducted by researchers at Karolinska Institutet, the study involved 35 participants and showed significant improvement in depressive symptoms compared to a placebo. While the treatment was generally well tolerated, the long-term effects and need for repeated treatments remain uncertain.
- ▪The study was randomized and double-blind, focusing on psilocybin's effects on common depression.
- ▪Participants receiving psilocybin showed a significant decrease in depression scores compared to those receiving a placebo.
- ▪After six weeks, 53% of the psilocybin group were in remission, compared to only 6% in the placebo group.
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| Original publisher | Ki |
| Canonical URL | https://news.ki.se/single-dose-of-psilocybin-provided-rapid-relief-from-depression-in-new-study |
| Publication time | Sat, 16 May 2026 11:02:44 +0000 |
| Retrieval time | 2026-05-16T11:10:18.318Z |
| Last seen | 2026-05-16T11:10:18.318Z |
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Published: 15-05-2026 17:00 | Updated: 15-05-2026 17:00Single dose of psilocybin provided rapid relief from depression in new studyImage: Caption:Photo: Getty ImagesA single dose of the psychedelic substance psilocybin can provide rapid relief from depressive symptoms – within just a few days. This is shown by the first randomised, double-blind study in Sweden of psilocybin for depression. The effect persisted for over three months, according to researchers at Karolinska Institutet.Depression is a public health problem that causes great suffering. SSRI drugs are the most common treatment, but many patients do not benefit from them.
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