Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function
A clinical trial investigated the effects of aspirin, acetaminophen, and ibuprofen on immune function in rhinovirus-infected volunteers. The study found that both aspirin and acetaminophen suppressed the serum neutralizing antibody response and increased nasal symptoms. There were no significant differences in viral shedding among the groups, but a trend towards longer shedding duration was noted in those taking aspirin and acetaminophen.
- ▪The trial involved sixty healthy volunteers who were infected with rhinovirus type 2.
- ▪Aspirin and acetaminophen were associated with a suppression of the antibody response and increased nasal symptoms.
- ▪No significant differences in viral shedding were observed, but a trend for longer duration was noted in the aspirin and acetaminophen groups.
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Record
| Original publisher | PubMed |
| Canonical URL | https://pubmed.ncbi.nlm.nih.gov/2172402/ |
| Publication time | Wed, 03 Jun 2026 05:10:13 +0000 |
| Retrieval time | 2026-06-03T05:41:56.797Z |
| Last seen | 2026-06-03T05:41:56.797Z |
| Headline source | Publisher (no WeSearch rewrite) |
| Excerpt source | publisher body |
| Excerpt method | First ~120 words (~800 chars) of extracted publisher body, fair-use limited. |
| Summary | WeSearch · cerebras-chat (WeSearch summarizer) |
| Summary source text | contentText |
| Citation coverage | Summary is a WeSearch-generated derivative; primary citation is the original publisher URL. |
| Cluster | vaqNLjMHlhbP |
| Cluster logic | Grouped by semantic title/content similarity across sources within a rolling window. Same-publisher template collisions are excluded from coverage comparison. |
| Ranking reason | Story pages are not engagement-ranked. Hub feeds use recency, with optional source-diversified chronological ordering (cap consecutive stories per source). No personalized ranking. |
| Publisher visit | Yes — open original |
| Substitutes article? | No — link-out required for full text |
Rights status (four layers)
WeSearch handling by dimension
| Indexing | May the item be indexed (stored, ranked, made findable)? | Allowed |
| Snippet | May a short excerpt of the publisher's text be shown? | Allowed |
| AI summary | May WeSearch generate its own short summary of the article? | Limited |
| Retrieval / RAG | May the content be exposed for third-party retrieval-augmented generation? | Not asserted |
| Model training | May the content be used to train AI models? | Not asserted |
| Commercial reuse | May the content be reused commercially? | Not permitted |
Basis: Derived from the published RSS/Atom feed. Contact: [email protected]. Reviewed: 2026-07-24.
Opening excerpt (first ~120 words) tap to expand
Clinical Trial J Infect Dis Actions Search in PubMed Search in NLM Catalog Add to Search . 1990 Dec;162(6):1277-82. doi: 10.1093/infdis/162.6.1277. Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers N M Graham 1 , C J Burrell, R M Douglas, P Debelle, L Davies Affiliations Expand Affiliation 1 Department of Community Medicine, University of Adelaide, South Australia. PMID: 2172402 DOI: 10.1093/infdis/162.6.1277 Item in Clipboard Clinical Trial Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers N M Graham et al. J Infect Dis. 1990 Dec.
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Excerpt limited to ~120 words for fair-use compliance. The full article is at PubMed.
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