Rethinking schizophrenia: insights from genomics and implications for research
Recent genomic research has provided new insights into the aetiology and pathogenesis of schizophrenia. It highlights the role of genetic and environmental factors across the lifespan, emphasizing that schizophrenia is primarily a neuronal disorder. These findings have significant implications for future research and understanding the heterogeneity of the condition.
- ▪Genetic risk for schizophrenia is expressed throughout the lifespan, from fetal development to adulthood.
- ▪Cognitive deficits and structural brain abnormalities are better understood as markers of neurodevelopmental vulnerability rather than causal mediators.
- ▪Non-familial genetic and environmental factors significantly influence neurodevelopmental impairment related to schizophrenia.
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| Original publisher | Nature |
| Canonical URL | https://www.nature.com/articles/s41380-026-03654-9 |
| Publication time | Mon, 25 May 2026 22:17:39 +0000 |
| Retrieval time | 2026-05-25T22:37:40.761Z |
| Last seen | 2026-05-25T22:37:40.761Z |
| Headline source | Publisher (no WeSearch rewrite) |
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| Summary | WeSearch · cerebras-chat (WeSearch summarizer) |
| Summary source text | contentText |
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| Cluster | tW4zqUPLKwxh |
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| Publisher visit | Yes — open original |
| Substitutes article? | No — link-out required for full text |
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| AI summary | May WeSearch generate its own short summary of the article? | Limited |
| Retrieval / RAG | May the content be exposed for third-party retrieval-augmented generation? | Not asserted |
| Model training | May the content be used to train AI models? | Not asserted |
| Commercial reuse | May the content be reused commercially? | Not permitted |
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Download PDF Expert Review Open access Published: 21 May 2026 Rethinking schizophrenia: insights from genomics and implications for research Michael J. Owen ORCID: orcid.org/0000-0003-4798-08621,2 & Michael C. O’Donovan ORCID: orcid.org/0000-0001-7073-23791,2 Molecular Psychiatry (2026) Cite this article 1520 Accesses 3 Altmetric Metrics details Subjects GeneticsSchizophrenia AbstractRecent genomic research, considered in the wider context of knowledge from outside genomics, provides significant conceptual insights into the aetiology and pathogenesis of schizophrenia. The evidence indicates that genetic risk is expressed across the lifespan, from foetal development through to adulthood, and involves multiple neuronal types and brain regions.
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Excerpt limited to ~120 words for fair-use compliance. The full article is at Nature.
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